Attack Cause Game to go into load loop!

Location:  Dark Tower 2nd floor ghoul fight

The ghoul encounter in the rooms after exiting the teleport

Last ghoul in battle with a sliver of health.

I click on the ghoul with my Paladin.  She is attacking with a non-magical great sword.  The moment after I click; the entire UI vanishes and nothing else happens.  When I tried to exit the game to reload a save I land on an infinite loading screen and have to use task manager to exit the game.  Prior to the most recent patch I never encountered with issue with over 115 hours in the game.